Advantage of Viscosupplementation for Knee OA Questioned

THURSDAY, July 14, 2022 (HealthDay Information) — Viscosupplementation yields a small discount in ache for knee osteoarthritis in contrast with placebo, which is lower than the minimal clinically vital between-group distinction, in line with a overview printed on-line July 6 in The BMJ.

Tiago V. Pereira, Ph.D., from the Li Ka Shing Information Institute at St. Michael’s Hospital in Toronto, and colleagues performed a scientific overview and meta-analysis of randomized trials to look at the effectiveness and security of viscosupplementation for ache and performance in sufferers with knee osteoarthritis. Knowledge have been included from 169 trials with 21,163 randomly assigned contributors.

The researchers discovered that primarily based on 24 trials, with 8,997 randomly assigned contributors, viscosupplementation was related to a small discount in ache depth versus placebo (standardized imply distinction [SMD], −0.08; 95 p.c confidence interval, −0.15 to −0.02); the decrease sure of the 95 p.c confidence interval excluded the minimal clinically vital between-group distinction (−0.37). This impact corresponded with a −2.0 mm distinction in ache scores on a 100-mm visible analog scale. In a sequential evaluation of trials for ache, since 2009, there was conclusive proof of medical equivalence between viscosupplementation and placebo. Based mostly on 15 giant placebo-controlled trials involving 6,462 contributors, an elevated danger for critical opposed occasions was seen with viscosupplementation versus placebo (relative danger, 1.49).

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“Our findings don’t assist the broad use of viscosupplementation for the remedy of knee osteoarthritis,” the authors write.

One writer disclosed monetary ties to the pharmaceutical and medical gadget industries.

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